SCHISANDRIN B TARGETS CDK4/6 TO SUPPRESS PROLIFERATION AND ENHANCE RADIOSENSITIVITY IN NASOPHARYNGEAL CARCINOMA BY INDUCING CELL CYCLE ARREST

Schisandrin B targets CDK4/6 to suppress proliferation and enhance radiosensitivity in nasopharyngeal carcinoma by inducing cell cycle arrest

Abstract Nasopharyngeal carcinoma (NPC) is notably prevalent in East EROSYN FOR WOMEN and Southeast Asia, where despite advancements in radiotherapy leading to high control rates, challenges like radioresistance and collateral tissue damage remain significant.While Schisandrin B (SchB) has been demonstrated antitumor effects in various tumors, its

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A Bayesian System to Detect and Track Outbreaks of Influenza-Like Illnesses Including Novel Diseases: Algorithm Development and Validation

Background The early identification Role Play Toys of outbreaks of both known and novel influenza-like illnesses (ILIs) is an important public health problem.Objective This study aimed to describe the design and testing of a tool that detects and tracks outbreaks of both known and novel ILIs, such as the SARS-CoV-2 worldwide pandemic, accurately an

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Methods of Selenium Application Differentially Modulate Plant Growth, Selenium Accumulation and Speciation, Protein, Anthocyanins and Concentrations of Mineral Elements in Purple-Grained Wheat

Selenium (Se) is an essential micronutrient for human health.Deficiency and suboptimality of Se in human populations are a potential health risk.The reduction of such health risk by biofortification of crops, particularly in wheat has drawn much attention, especially for color-grained wheat Rolling Papers as it is rich in anthocyanins and can be us

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Differential target multiplexed spinal cord stimulation using a paddle-type lead placed at the appropriate site for neuropathic pain after spinal cord injury in patients with past spinal surgical histories: study protocol for an exploratory clinical trial

Abstract Background Neuropathic pain after spinal cord injury (SCI), both traumatic and non-traumatic, is refractory to various treatments.Spinal cord stimulation (SCS) is one of the neuromodulation therapies for neuropathic pain, although SCS has insufficient efficacy for neuropathic pain after SCI.The reasons are presumed to be inappropriate loca

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